Amoskeag, or Namaskeak, is said to mean “great fishing place.” It was hereabouts that the Sachem Wannalancet resided. Tradition says that his tribe, when at war with the Mohawks, concealed their provisions in the cavities of the rocks in the upper part of these falls.
Henry David Thoreau
In May 1807, Samuel Blodget completed a canal and lock system beside the Merrimack River at Derryfield. His enterprise allowed boats traveling between Concord and Nashua to bypass Amoskeag Falls, opening the region to development. Blodget envisioned here “the Manchester of America,” a water-powered textile center comparable to the Industrial Revolution English city he had recently visited. The name stuck, and in 1810 Derryfield was changed to Manchester. That same year, Benjamin Prichard and others incorporated the Amoskeag Cotton & Woolen Manufacturing Company.
Amoskeag Manufacturing Company entry in Wikipedia